What should your Adrenaline Auto-Injectors look like?

What should your Adrenaline Auto-Injectors look like?

  • 13 November 2025
  • News

Following some recent queries, we’ve put together a few tips to help you check whether your Adrenaline Auto-Injectors (AAIs) need replacing. 

Adrenaline is the first-line treatment for serious allergic reactions (anaphylaxis). It is available on prescription in a pre-loaded injection device (such as EpiPen® or Jext®) and, more recently, as an intranasal, needle-free nasal spray known as Eurneffy®. 

In this article, we highlight what your AAIs should look like and how to know when they need to be replaced. Please note that this guidance does not cover Eurneffy®. 

Our top tips 

1. Check that your AAIs are in date 

Life can get busy, and it’s easy to lose track of expiry dates — but this is vital for your safety. To make it easier, you can sign up for a free expiry alert service from your AAI manufacturer: 

If your AAIs have already expired, contact your GP as soon as possible to order a replacement. Ideally you should replace your AAIs one month before they are due to expire.  

2. Check the liquid inside the device 

Look at the viewing window on your EpiPen® or Jext® regularly. The liquid inside should be clear and colourless.

If the solution appears discoloured (pinkish or brownish) or contains particles, it should be replaced immediately. 

A change in colour can indicate that the adrenaline has degraded, possibly due to exposure to air, heat, or light, and it may no longer be effective.  

3. Store your AAIs correctly 

Adrenaline can be affected by extreme temperatures, so proper storage is essential: 

  • Keep your AAIs in their original container to protect them from light. 
  • Avoid storing them in very hot or cold places. AAIs should be stored at room temperature, below 25°C. 
  • Consider storing your AAIs in an insulated bag to protect your devices. You need to look for medical grade insulin bags. 

If you have any concerns or would like more information about how to store or use your AAIs, please refer to our Adrenaline Factsheet or contact our Helpline for further support.