Mylan UK has released an updated EpiPen® demonstration video to reflect changes to instructions on the administration of EpiPen® and EpiPen® Junior adrenaline auto-injector, which is available to view on Vimeo.
More information about the changes are also detailed in a statement available on the www.epipen.co.uk website, as follows 
Mylan UK has recently received approval for a change to the instructions for use of EpiPen® and EpiPen® Junior. There is no change to the device or the drug (adrenaline); the change is in the instructions for use as outlined below:
- Reduced holding time from 10 to 3 seconds.
- Removal of the massage step after administration.
- The changes are aimed to simplify the process and improve compliance.
- It is important to remember, the effectiveness of the EpiPen® and EpiPen® Junior will not be impacted
regardless of whether it is held for 3 or 10 seconds.
- We expect EpiPen® and EpiPen® Junior with the new instructions to enter pharmacies in the UK from
November 2017 onwards, and these will gradually replace the 10 second labelled pen. As we go through
the transition period, there will still be some EpiPen® and EpiPen® Junior with the 10 second label
available in the UK.
- If you have an EpiPen® with the 10 second label, you don’t need to get it replaced. EpiPen®’s only need
to be replaced when they have been used or when they are about to expire.
- All EpiPen®’s should be used following these new instructions. The pen should be held for 3 seconds and there is no need to massage. If a patient forgets, and holds the EpiPen® for 10 seconds and/or massages the site, it won’t affect the way the EpiPen® works.
The adrenaline auto-injectors prescribed in the UK at present are Emerade®, EpiPen® and Jext®. The Anaphylaxis Campaign has contacted ALK the pharmaceutical company that produces Jext® and Bausch and Lomb who produce Emerade® who have informed us that they have, at present, no plans the change the method of administration of their adrenaline auto-injectors.
The place where the adrenaline is administered is the same for all three injectors; Emerade®, EpiPen® and Jext® are injected into the muscle in the front quarter of the outer thigh. However, the method of administration for each autoinjector varies slightly. Training should be given to all those who might be required to administer the adrenaline in an emergency, such as family members and friends. You can also find help on the website relevant to the injector you carry. For Emerade® visit www.emerade-bausch.co.uk, for EpiPen® visit www.epipen.co.uk and for Jext® visit www.jext.co.uk.
If you have any concerns or questions, please contact our helpline team at [email protected] or call 01252 542 029.
With reference to the new SmPC guidelines MYLAN UK, www.epipen.co.uk [online] 15h December 2017, www.epipen.co.uk