Anaphylaxis is a severe allergic reaction -
the extreme end of the allergic spectrum. The whole body is
affected, often within minutes of exposure to the allergen
but sometimes after hours. Peanut allergy and nut allergy
are frequently severe and for that reason have received widespread
publicity. Causes of anaphylaxis also include other foods,
insect stings, latex and drugs, but on rare occasions there
may be no obvious trigger.
Some people find that the allergy symptoms they experience
are always mild. For example, there may be a tingling or itching
in the mouth, or a localised rash - nothing more. This is not serious
in itself, and may be treated with oral antihistamines. However,
in some cases the allergy may become worse over time. It is wise in
all cases to make an appointment with the doctor and seek a referral
to a specialist allergy clinic.
If there is marked difficulty in breathing or swallowing,
and/or a sudden weakness or floppiness, regard these as serious
symptoms requiring immediate treatment.
Pre-loaded adrenaline injection kits are available
on prescription for those believed to be at risk. These are available
in two strengths - adult and junior.
The injection must be given, as directed, as soon
as a serious reaction is suspected and an ambulance must be called.
If there is no improvement in 5-10 minutes, give a second injection.
Any allergic reaction, including the most extreme
form, anaphylactic shock, occurs because the body's immune system
reacts inappropriately in response to the presence of a substance
that it wrongly perceives as a threat.
An anaphylactic reaction is caused by the sudden release
of chemical substances, including histamine, from cells in the blood
and tissues where they are stored. The release is triggered by the
reaction between the allergic antibody (IgE) with the substance
(allergen) causing the anaphylactic reaction. This mechanism
is so sensitive that minute quantities of the allergen can cause
a reaction. The released chemicals act on blood vessels to cause
the swelling in the mouth and anywhere on the skin. There is a fall
in blood pressure and, in asthmatics, the effect is mainly on the
lungs.
During anaphylaxis, blood vessels leak, bronchial
tissues swell and blood pressure drops, causing choking and collapse.
Adrenaline (epinephrine) acts quickly to constrict blood
vessels, relax smooth muscles in the lungs to improve breathing,
stimulate the heartbeat and help to stop swelling around the face
and lips (angioedema).
If you have suffered a bad allergic reaction in the past – whatever the cause – then any future reaction is also likely to be severe. If you have suffered a significant reaction to a tiny dose, or have reacted on skin contact, this might also be a sign that a larger dose may trigger a severe reaction. If you have asthma as well as allergies, a referral is particularly important because asthma can put you in a higher risk category. Where foods such as nuts, seeds, shellfish and fish are concerned, even mild symptoms should not be ignored because future reactions may be severe. For a list of NHS allergy clinics, GPs can refer to the website of the British Society for Allergy and Clinical Immunology: www.bsaci.org
Common causes include foods such as peanuts, tree
nuts (e.g. almonds, walnuts, cashews, Brazils), sesame, fish, shellfish,
dairy products and eggs. Non-food causes include wasp or bee stings,
natural latex (rubber), penicillin or any other drug or injection.
In some people, exercise can trigger a severe reaction - either
on its own or in combination with other factors such as food or
drugs (e.g. aspirin).
Fresh fruit allergy may occur in people who are allergic
to pollen. This is frequently mild, but a doctor's advice should
be sought.
There is no perfect way to measure an individual's
potential for a severe allergic reaction, but, in making a diagnosis,
an allergy consultant can do several things that will provide clues.
Most importantly, the specialist will take a detailed history of
previous reactions and other allergic conditions you may have. Valuable
information can also be provided by means of skin prick tests and
blood tests (R.A.S.T. or CAP assay).
Minimise the risk by taking great care and being
vigilant. If you are food allergic, read labels like Sherlock
Holmes: look for the "hidden" allergen. You can easily recognise
a packet of peanuts but may miss the word "groundnuts" in tiny
print on the side of a tin of curry sauce, or the Latin term arachis
used to signify the presence of peanut in pharmaceutical products.
If you are food-allergic, be assertive about asking
for detailed information from manufacturers and supermarket staff.
Be particularly careful in restaurants, where proprietors
are under no obligation to list ingredients. Question staff very
directly. It may be necessary to speak with a senior manager.
Some restaurants have ingredient lists available for you to check.
You may wish to telephone the restaurant in advance to ensure
your allergy is taken seriously.
Be alert to all symptoms and take them seriously.
Reach for the adrenaline (epinephrine) if you think you are beginning
to show signs of a severe reaction. Do not wait until you are
sure. Even if adrenaline is administered, you will still need
to get to hospital as soon as possible. Someone must call an ambulance.
Make sure others in your family know how to administer
the adrenaline kit - and when. Do not be frightened of adrenaline.
It is a well-understood drug. The dose you will administer has
very few side effects, which will pass quickly in any case. However,
if you have heart difficulties, discuss these with your doctor.
Develop a crisis plan for how to handle an emergency.
Get your allergist or GP to help. Have this written out for family
and friends - put it on the bulletin board at home; carry one
in your pocket. If a child is the person at risk, make sure his
teachers and friends' parents have a copy - along with the adrenaline.
Make sure everyone knows where the adrenaline is when you go out,
or when you are at home.
Wear a MedicAlert talisman (details: 020 7833
3034).
Be open about your allergy problem with your family,
friends and colleagues. It's easy to avoid a Thai, Chinese or
Indian restaurant if everyone knows you are allergic to peanuts.
What
should I do if I think I am having a serious reaction?
Follow your crisis plan. These are some key points:
Is there a marked difficulty in breathing or swallowing?
Is there sudden weakness or floppiness? Is there a steady deterioration?
Any of these are signs of a serious reaction.
Administer adrenaline (epinephrine) without delay
if you believe the symptoms are serious, or becoming serious.
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