Birth cohort study findings using prospective food diary data.
An article in press in the Journal of Allergy and Clinical Immunology seeks to assess the relationship between infant dietary patterns in the first year of life and development of food allergy by age 2 years and concludes:
An infant diet consisting of high levels of fruits, vegetables, and home-prepared foods is associated with less food allergy by the age of 2 years.
Read the abstract.
The American study detailed above, has been published in the Journal of Allergy & Clinical Immunology : In Practice
“With the rising prevalence of atopic disease, primary prevention may play a role in reducing its burden, especially in high-risk infants. With this in mind, the Adverse Reactions to Foods Committee of the American Academy of Allergy, Asthma & Immunology was charged with the task of developing recommendations for primary care physicians and specialists about the primary prevention of allergic disease through nutritional interventions according to current available literature and expert opinion. Recommendations that are supported by data are as follows. Avoidance diets during pregnancy and lactation are not recommended at this time, but more research is necessary for peanut. Exclusive breast-feeding for at least 4 and up to 6 months is endorsed. For high-risk infants who cannot be exclusively breast-fed, hydrolyzed formula appears to offer advantages to prevent allergic disease and cow’s milk allergy. Complementary foods can be introduced between 4 and 6 months of age. Because no formal recommendations have been previously provided about how and when to introduce the main allergenic foods (cow’s milk, egg, soy, wheat, peanut, tree nuts, fish, shellfish), these are now provided, and reasons to consider allergy consultation for development of a personalized plan for food introduction are also presented.”
Read the full paper.
A provisional copy of “Peanut Allergen Threshold Study (PATS): validation of eliciting doses using a novel single-dose challenge protocol” has been published in the Allergy, Asthma & Clinical Immunology Journal
The eliciting dose (ED) for a peanut allergic reaction in 5% of the peanut allergic population, the ED05, is 1.5 mg of peanut protein. The aim of the study was to assess the precision of the predicted ED05 using a single dose (6 mg peanut = 1.5 mg of peanut protein) in the form of a cookie.
The study concludes:
The validation of the ED05 threshold for allergic reactions in peanut allergic subjects has potential value for public health measures. The single dose OFC, based upon the statistical dose-distribution analysis of past challenge trials, promises an efficient approach to identify the most highly sensitive patients within any given food-allergic population.
Read the full provisional text here.
A new update to the 2011 WAO Anaphylaxis Guidelines for management of anaphylaxis in health care settings and community settings has been published.
The 2013 Update highlights publications from 2012 and 2013 that further contribute to the evidence base for the recommendations made in the original WAO Anaphylaxis Guidelines.
Ideally, it should be used in conjunction with these Guidelines and with the 2012 Guidelines Update.
Read the full update here.
“Concomitant chronic pulmonary diseases and their association with hospital outcomes in patients with anaphylaxis and other allergic conditions: a cohort study”has been published as a BMJ open article and concludes that :“asthma, COPD and other chronic pulmonary diseases increased the risk of adverse outcomes among hospitalised patients with anaphylaxis.”
Read the full article.
Trade organisation Community Pharmacy Scotland has invited its 1,250 affiliated pharmacies to provide trained emergency anaphylaxis relief, with over half already on board.
Pharmacies which provide the service will display an orange cross in their windows, signifying that emergency anaphylaxis treatment is available
Liberal Democrat MP for East Dunbartonshire, Jo Swinson is backing the Campaign . Jo has a severe nut allergy and had a severe reaction after eating a biscuit that contained nuts at a charity cake sale earlier this year .
Wherever a pharmacy displays an orange cross, people should be reassured that they can get trained help. That means that throughout Scotland's cities, towns and villages, hundreds of community pharmacies should be geared up to help in an emergency.
Read more here.
The Journal of Emergency Medicine has published an article on “Customizing Anaphylaxis Guidelines for Emergency Medicine"
The article concludes that the working definition of anaphylaxis and the supporting Consensus Statements devised by a multidisciplinary group of experts attending a July 2011 Roundtable meeting, Anaphylaxis in Emergency Medicine in Chicago, who were given the directive of reviewing current guidelines and how they are applied in different emergency medical settings in the US (e.g., prehospital, community hospital, rural health care, academia medical center) are a first step to better management of anaphylaxis in the emergency medical setting.
Medscape access required.