Anaphylaxis
- the basic facts
Anaphylaxis is a severe allergic reaction - the extreme end of the allergic spectrum. The whole body is affected, often within minutes of exposure to the allergen but sometimes after hours. Peanut allergy and nut allergy are frequently severe and for that reason have received widespread publicity. Causes of anaphylaxis also include other foods, insect stings, latex and drugs, but on rare occasions there may be no obvious trigger.
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experience all of these symptoms. Some people find that the allergy symptoms they experience are always mild. For example, there may be a tingling or itching in the mouth, or a localised rash - nothing more. This is not serious in itself, and may be treated with oral antihistamines. However, in some cases the allergy may become worse over time. It is wise in all cases to make an appointment with the doctor and seek a referral to a specialist allergy clinic. If there is marked difficulty in breathing or swallowing,
and/or a sudden weakness or floppiness, regard these as serious symptoms
requiring immediate treatment. What is the treatment for a severe reaction? Pre-loaded adrenaline injection kits are available on prescription for those believed to be at risk. These are available in two strengths - adult and junior. The injection must be given, as directed, as soon as a serious
reaction is suspected and an ambulance must be called. If there is no
improvement in 5-10 minutes, give a second injection. Any allergic reaction, including the most extreme form,
anaphylactic shock, occurs because the body's immune system reacts inappropriately
in response to the presence of a substance that it wrongly perceives as
a threat. An anaphylactic reaction is caused by the sudden release
of chemical substances, including histamine, from cells in the blood and
tissues where they are stored. The release is triggered by the reaction
between the allergic antibody (IgE) with the substance (allergen)
causing the anaphylactic reaction. This mechanism is so sensitive that
minute quantities of the allergen can cause a reaction. The released chemicals
act on blood vessels to cause the swelling in the mouth and anywhere on
the skin. There is a fall in blood pressure and, in asthmatics, the effect
is mainly on the lungs. During anaphylaxis, blood vessels leak, bronchial tissues
swell and blood pressure drops, causing choking and collapse. Adrenaline
(epinephrine) acts quickly to constrict blood vessels, relax smooth
muscles in the lungs to improve breathing, stimulate the heartbeat and
help to stop swelling around the face and lips (angioedema). How do I know if I am at risk from anaphylaxis? If you have suffered a bad allergic reaction in the past – whatever the cause – then any future reaction is also likely to be severe. If you have suffered a significant reaction to a tiny dose, or have reacted on skin contact, this might also be a sign that a larger dose may trigger a severe reaction. If you have asthma as well as allergies, a referral is particularly important because asthma can put you in a higher risk category. Where foods such as nuts, seeds, shellfish and fish are concerned, even mild symptoms should not be ignored because future reactions may be severe. For a list of NHS allergy clinics, GPs can refer to the website of the British Society for Allergy and Clinical Immunology: www.bsaci.org What are the most common causes of anaphylaxis? Common causes include foods such as peanuts, tree nuts (e.g. almonds, walnuts, cashews, Brazils), sesame, fish, shellfish, dairy products and eggs. Non-food causes include wasp or bee stings, natural latex (rubber), penicillin or any other drug or injection. In some people, exercise can trigger a severe reaction - either on its own or in combination with other factors such as food or drugs (e.g. aspirin). Fresh fruit allergy may occur in people who are allergic
to pollen. This is frequently mild, but a doctor's advice should be sought.
What will an allergy specialist do? There is no perfect way to measure an individual's potential
for a severe allergic reaction, but, in making a diagnosis, an allergy
consultant can do several things that will provide clues. Most importantly,
the specialist will take a detailed history of previous reactions and
other allergic conditions you may have. Valuable information can also
be provided by means of skin prick tests and blood tests (R.A.S.T.
or CAP assay).
What should I do if I think I am having a serious reaction? Follow your crisis plan. These are some key points:
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